Table of Contents

Reviews

4. Pharmacogenomics: The Promise of Personalized Medicine
Laviero Mancinelli, Maureen Cronin, Wolfgang Sadee

6. Targeted Prodrug Design to Optimize Drug Delivery
Hyo-Kyung Han and Gordon Amidon

Editorial

E-Publishing in 2000
Wolfgang Sadee

Original Research Articles

1. Pharmacokinetics of Nevirapine and Lamivudine in Patients with HIV-1 Infection
Thomas MacGregor, John Sabo, Michael Lamson, Gerhard Leitz, Chan-Loi Yong

2. Molecular Modeling of G-protein Coupled Receptor Kinase 2: Docking and Biochemical Evaluation of Inhibitors
Matthias Kassack, Petra Högger, Daniel Gschwend, Kimihiko Kameyama, Tatsuya Haga, Richard Graul, Wolfgang Sadée

3. Maturation and Growth of Renal Function: Dosing Renally Cleared Drugs in Children
William Hayton

5. Comparison of the Rates of Deamidation, Diketopiperazine Formation and Oxidation in Recombinant Human Vascular Endothelial Growth Factor and Model Peptides
Chimanlall Goolcharran, Jeffrey Cleland, Rodney Keck, Andrew Jones, and Ronald Borchardt

7. Synthesis and Characterization of Positively Charged tPA as a Prodrug Using Heparin/Protamine-Based Drug Delivery System
Jun Liang, Yong Li, Maureen Connell, and Victor Yang

8. Comparison of Methods for Analyzing Kinetic Data From Mechanism-Based Enzyme Inactivation: Application to Nitric Oxide Synthase
Tristan Maurer and Ho-Leung Fung

9. Comparative Evaluation of the Degree of Indomethacin Crystallinity by Chemoinfometrical Fourie-Transformed Near-Infrared Spectroscopy and Conventional Powder X-ray Diffractiometry
Makoto Otsuka, Fumie Kato, Yoshihisa Matsuda