Urtti A, Johns SJ and Sadee W Genomic Structure of Proton-Coupled Oligopeptide Transporter hPEPT1 and pH-Sensing Regulatory Splice Variant. AAPS PharmSci 2001; 3 (1) article 6 (https://www.pharmsci.org/scientificjournals/pharmsci/journal/01_06.html).

Figures and Tables

Figure 1.Gene structure and splicing of the hPEPT1 gene. hPEPT1 and hPEPT1-RF completely share exons 4-6 and partially share exons 3 and 7, where the alternative splice sites are located (indicated by the vertical lines). Exon 7' represents a repetitive element. Arrows indicate the translation start and stop sites. To view the interactive version with the exonic sequences available by clicking on the boxes (Click here to view).

Table 1. hPEPT1 gene (Click here to view)

Table 2. Exon-intron organization of hPEPT1-RF gene (Click here to view)

Figure 2.Membrane topology prediction for hPEPT1.  The prediction was carried out using the TOPPRED program. The exon boundaries are indicated by alternating color codes.

Figure 3.Membrane topology prediction for hPEPT1-RF.  The prediction was carried out using the TOPPRED program. The exon boundaries are indicated by alternating color codes.

Figure 4.Putative regulatory region of hPEPT1 gene. cDNA is shown as bold characters from transcription start site (position +1) to translation start site (atg). Nucleotides in the regulatory region are marked with negative numbers starting from the transcription start site. Promoter sites and some transcription factor binding sites are indicated as boxes. The corresponding factor is marked above the sequence. Orientation of the site is indicated by the numbers in parentheses.