Table of Contents

Reviews

22. Genetic Variations in Human G Protein-Coupled Receptors: Implications for Drug Therapy
Wolfgang Sadee, Elen Hoeg, Julie Lucas and Danxin Wang

Commentaries

Genotyping and Drug Response: Use of Single Nucleotide Polymorphisms (SNPs) versus Haplotypes to Predict Albuterol Efficacy
Suzanne Schubbert

UGT1A1 Polymorphism Predicts Irinotecan Toxicity: Evolving Proof
Sridhar Mani

The MDR1 C3435T polymorphism: Effects on P-glycoprotein expression/function and clinical significance
Mark J. Dresser

Original Research Articles

17. Low Molecular Weight Protamine (LMWP) as Nontoxic Heparin/Low Molecular Weight Heparin Antidote (I): Preparation and Characterization
Li-Chien Chang, Hsiao-Feng Lee, ZhiQiang Yang, and Victor C. Yang

18.Low Molecular Weight Protamine (LMWP)as Nontoxic Heparin/Low Molecular Weight Heparin Antidote (II): In Vitro Evaluation of Efficacy and Toxicity
Li-Chien Chang, Jun Feng Liang, Hsiao-Feng Lee, Lai Ming Lee, and Victor C. Yang

19. Low Molecular Weight Protamine as Nontoxic Heparin/Low Molecular Weight Heparin Antidote (III): Preliminary In Vivo Evaluation of Efficacy and Toxicity Using a Canine Model
Lai Ming Lee, Li-Chien Chang, Shirley Wrobleski, Thomas W. Wakefield, and Victor C. Yang

20. Comparative Evaluation of Tableting Compression Behaviors by Methods of Internal and External Lubricant Addition: Inhibition of Enzymatic Activity of Trypsin Preparation by Using External Lubricant Addition During the Tableting Compression Process
Makoto Otsuka, Mitsuyo Sato and Yoshihisa Matsuda

21. DNA/polyethylenimine transfection particles: Influence of ligands, polymer size, and PEGylation on internalization and gene expression
Manfred Ogris, Peter Steinlein, Sebastian Carotta, Sylvia Brunner and Ernst Wagner

23. Use of FT-NIR Transmission Spectroscopy for the Quantitative Analysis of an Active Ingredient in a Translucent Pharmaceutical Topical Gel Formulation
Mark S. Kemper, Edgar J. Magnuson, Stephen R. Lowry, William J. McCarthy, Napasinee Aksornkoae, D. Christopher Watts, James R. Johnson and Atul J. Shukla

24. Influence of Drug Release Properties of Conventional Solid Dosage Forms on the Systemic Exposure of Highly Soluble Drugs
Lawrence X. Yu, Christopher D. Ellison, Dale P. Conner, Larry J. Lesko and Ajaz S. Hussain

25. Comparison of the Gravimetric, Phenol Red, and 14C-PEG-3350 Methods to Determine Water Absorption in the Rat Single-Pass Intestinal Perfusion Model
Steven C. Sutton, M.T.S. Rinaldi and K.E. Vukovinsky