Kleinebudde P, Jumaa M and Saleh F Influence of the Degree of Polymerization on the Behavior of Cellulose During Homogenization and Extrusion/Spheronization AAPS PharmSci 2000; 2 (3) article 21 (https://www.pharmsci.org/scientificjournals/pharmsci/journal/21.html).

Figures and Tables

Table 1. Properties of Microcrystalline Cellulose the Various Investigated Cellulose Types

*Mean particle size [D₅₀] of 9% presuspension before the homogenization.

**Mean particle size [D₅₀] of dry cellulose powder.

Figure 1.Cellulose behavior (microcrystalline and powdered) with various degree of polymerization values during the homogenization process after different cycles at 40 MPa.

Figure 2.Correlation between the particle size and the degree of polymerization values after the homogenization process (6 cycles, 40 MPa).

Figure 3.Influence of homogenization cycles at 40 MPa pressure on the apparent viscosity of different microcrystalline and powdered cellulose types.

Figure 4.Dried filter cakes of homogenized suspensions of different cellulose types.

Figure 5.Effect of the degree of polymerization of the used cellulose on the extrudate water content and pellet porosity.

Figure 6.Influence of the degree of polymerization on the fracture force.

Figure 7.Correlation between particle size D₅₀ and D₉₉ of the various investigated cellulose types after homogenization (6 cycles, 40 MPa) with the extrudate water content.

Figure 8.Scanning electron microscope pictures of the starting powders and the surface of the resulting pellets for DP225 (Avicel PH101) and DP1431 (Elcema P050).

Table 2. Comparison Between the Behavior of Cellulose With Low and High DP