Conkins D, Economou JE, Boersma JA, Dedhiya MG and Hansen G Reversed Phase-High Performance Liquid Chromatographic (RP-HPLC) Method to Measure Migration of Semi-Volatile Compound, Vanillin, in Ipratropium Bromide Inhalation Solution AAPS PharmSci 1999; 1 (4) article 15 (https://www.pharmsci.org/scientificjournals/pharmsci/journal/99_15.html).

Figures and Tables

Figure 1.Structure formulas of ipratropium bromide,tropic acid, and vanillin

Table 1. HPLC operating conditions

Table 2. Summary of composition and packaging configurations

Figure 2.RP-HPLC chromatogram of ipratropium bromide, tropic acid, and vanillin

Figure 3.Linearity of vanillin in ipratropium bromide solution

Table 3. Vanillin concentration (ng/mL) in the commercial ipratropium bromide solution products