DeLuca PP and Dani BA Skeletal Effects of Parathyroid Hormone (1-34) in Ovariectomized Rats With or Without Concurrent Administration of Salmon Calcitonin AAPS PharmSci 2001; 3 (4) article 27 (https://www.pharmsci.org/scientificjournals/pharmsci/journal/01_27.html).

Figures and Tables

Table 1. Treatment Regimens of PTH Injection or Infusion to OVX and Sham-Operated Rats With or Without Concurrent Infusion of sCT

Figure 1.Serum PTH levels after 4 weeks of infusion of 40 µ g/kg/day of PTH in female Sprague-Dawley rats using Alzet osmotic pumps (n = 5). The zero time average is the average serum PTH level before the treatments were started.

Figure 2.Serum sCT levels after 4 weeks of infusion of 10 µ g/kg/day of sCT in female Sprague-Dawley rats using Alzet osmotic pumps (n = 5). The zero time average is the average serum sCT level before the treatments were started.

Figure 3.Effect of administration of PTH either continuously or intermittently (daily injections) with or without continuous infusion of sCT on body weights of ovariectomized rats. 1. PTH infusion alone. 2. PTH + sCT infusion. 3. sCT infusion + daily PTH injection. 4. Daily PTH injection. 5. Vehicle. 6. Vehicle + sham-operated rats. The number of rats in each group is reported in Table 1 .

Figure 4.Effect of administration of PTH either continuously or intermittently (daily injections) with or without continuous infusion of sCT on cancellous bone volume of ovariectomized rats. a indicates results significantly different from those of group 5; b, significantly different from group 6; c, significantly different from group 2. The number of rats in each group is reported in Table 1 .