Human Membrane Transporter Database: A Web-Accessible Relational Database for Drug Transport Studies and Pharmacogenomics by Qing Yan and Wolfgang Sadee - Keywords: Drug Transporters, Pharmacogenomics, Relational Database, Web

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Scientific Journals: AAPS PharmSci

Yan Q and Sadee W Human Membrane Transporter Database: A Web-Accessible Relational Database for Drug Transport Studies and Pharmacogenomics AAPS PharmSci 2000; 2 (3) article 20 (https://www.pharmsci.org/scientificjournals/pharmsci/journal/20.html).

Figures and Tables

Table 1. Sample database hyperlinks in HMTL

LINK	URL
Entrez	https://www.ncbi.nlm.nih.gov/Entrez/
OMIM (Online Medalian Inheritance in Man)	https://www.ncbi.nlm.nih.gov/Omim/
HGMD (Human Gene Mutation Database)	https://www.uwcm.ac.uk/uwcm/mg/hgmd0.html
GDB (Genome Database)	https://www.gdb.org/
PubMed	https://www.ncbi.nlm.nih.gov/PubMed/
Genes and Disease Map	https://www.ncbi.nlm.nih.gov/disease/Transporters.html
dbSNP (Database of Single NucleotidePolymorphisms)	https://www.ncbi.nlm.nih.gov/SNP/index.html

Figure 1.The structure of HMTD.

Figure 2.Database Front End: the HTML page.

Figure 3.The architecture of HMTD: the three-tiered Web database application.

Figure 4.The sample result of the query "What tissue is OATP expressed in?"

Table 2. Sample queries for HMTD

For a given transporter	What are the substrates? What polymorphisms are known? What are the gene and protein sequences? What is the chromosomal location? What are the associated diseases and disorders? In which tissues can it be found?

For a substrate/drug	Which transporters are known to interact with it?

For a given tissue	Which transporters are expressed in it?

Table 3. Some sample results of the queries: "Which transporters are expressed in the intestine (or kidney, or brain) tissue?"