Preliminary Program

Thursday | Friday

Thursday, April 25

7:30 am – 5:30 pm
Registration

8:30 am – 12:00 pm
Session I: Fundamental Principles Related to Salt Selection and General Issues
Moderators
Mandar V. Dali, Ph.D.
Madhu Pudipeddi, Ph.D.

8:30 am – 8:40 am
Welcoming Remarks
Mandar V. Dali, Ph.D.
Bristol-Myers Squibb Company

8:40 am – 8:50 am
Workshop Introduction
Madhu Pudipeddi, Ph.D.
Novartis Pharmaceuticals Corporation

8:50 am – 9:30 am
Fundamental Physicochemical Principles Governing Salt Selection
Bradley D. Anderson, Ph.D.
University of Kentucky

9:30 am – 10:10 am
Oral Absorption and Other Biopharmaceutical Considerations in Salt Selection
Christos Reppas, Ph.D.
University of Athens

10:10 am – 10:30 am
Break

10:30 am – 11:15 am
Salt Form of Free Species: Making the Right Decision
Joseph B. Bogardus, Ph.D.
Bristol-Myers Squibb Company

11:15 am – 12:00 pm
Panel Discussion

12:00 pm – 1:30 pm
Lunch
Complimentary to all registrants

1:30 pm – 5:30 pm
Session II: Strategies in Salt Selection Process
Moderators
Madhu Pudipeddi, Ph.D.
Olafur Gudmundsson, Ph.D.

1:30 pm – 2:10 pm
A Systematic Approach to the Identification of Chemical and Physical Forms
Abu Serajuddin, Ph.D.
Novartis Pharmaceuticals Corporation

2:10 pm – 2:50 pm
Chemical Processing and Scale-Up Considerations in Salt Form Selection
Speaker To Be Announced

2:50 pm – 3:10 pm
Break

3:10 pm – 3:50 pm
Expediting the Salt Selection Process: High Throughput Screening
Arjen van Langeveld
Crystallics BV

3:50 pm – 4:30 pm
Nucleation and Crystal Growth of Polymorphs Relevant to Screening
David J.W. Grant, Ph.D.
University of Minnesota

4:30 pm – 5:30 pm
Panel Discussion

5:30 – 6:30 pm
Reception

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Friday, April 26

8:00 am – 12:00 pm
Registration

8:30 am – 12:00 pm
Session III: Physicochemical Characterization of Salts and Polymorphs – Case Studies
Moderators
Olafur Gudmundsson, Ph.D.
Abu Serajuddin, Ph.D.

8:30 am – 9:10 am
Analytical Techniques Used in the Solid State Characterization of Pharmaceutical Salts and Polymorphs
David Bugay, Ph.D.
SSCI

9:10 am – 9:50 am
Amorphous Versus Crystalline: Can We Make an Informed Decision?
Sheri Shamblin, Ph.D.
Pfizer, Inc.

9:50 am – 10:10 am
Break

10:10 am – 10:50 am
Salt Form Selection: Case Studies
Shyam B. Karki, Ph.D.
Merck & Company, Inc.

10:50 am – 12:00 pm
Panel Discussion

12:00 pm – 1:30 pm
Lunch
Complimentary to all registrants

1:30 pm – 4:00 pm
Session IV: General Topics
Moderators
Mandar V. Dali, Ph.D.
Abu Serajuddin, Ph.D.

1:30 pm – 2:10 pm
Intellectual Property and Salt Selection: Patents 101
Laura Bauer
Law Firm of Fitzpatrick, Cella, Harper & Scinto

2:10 pm – 2:50 pm
Toxicological and Regulatory Considerations in Salt Selection
Speaker To Be Announced

2:50 pm – 3:10 pm
Break

3:10 pm – 3:50 pm
Panel Discussion

3:50 pm – 4:00 pm
Closing Remarks
Mandar V. Dali, Ph.D.
Bristol-Myers Squibb Company

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AAPS Workshop on Chemical and Physical Form Selection of Drug Candidates: Principles, Considerations and Case Studies
April 25-26, 2002, Crystal Gateway Marriott, Arlington, VA