Past Local Events

First Annual Meeting on Advances in Pharmaceutical Sciences
May 28-29, 1998
Univ. of Mississippi, Yerby Center

Program Information and Registration

The AAPS Southern Regional Discussion Group in cooperation with The University of Mississippi School of Pharmacy presents the First Annual Meeting on Advances in Pharmaceutical Sciences on May 28-29, 1998, at The University of Mississippi - Oxford Campus, Yerby Conference Center. The submitted podium and poster presentations are from the following areas of pharmaceutical interest: Analysis and Pharmaceutical Quality (APQ); Biotechnology (BIOTECH); Medicinal and Natural Products Chemistry (MNPC); Pharmaceutics and Drug Delivery (PDD); Pharmacokinetics, Pharmacodynamics, and Drug Metabolism (PPDM); and Pharmaceutical Technologies (PT). The deadline for early registration is May 8th, 1998 ($35.00 for professional members, $15.00 for students and post-docs). Registration received after May 8th will be $60.00 for professional members, and $25.00 for graduate students and post-docs. The registration fee includes the reception on May 28th, and the continental breakfast and lunch on May 29th. All registration inquiries should be forwarded to Russell Cooper at (601) 232-7282, drcooper@olemiss.edu.

Program Schedule

Thursday, May 28, 1998
2:00 p.m. - 4:00 p.m.
Registration, Yerby Center

4:00 p.m. - 5:00 p.m.
Tour of the National Center for the Development of Natural Products (NCDNP) and the School of Pharmacy, will meet in front of NCDNP.

5:00 p.m. - 6:00 p.m.
Tour of The University of Mississippi and Oxford, Departure from Faser Hall.

6:30 p.m. - 8:00 p.m.
Welcoming Reception, Memory House

8:00 p.m. - 8:30 p.m.
AAPS-SRDG Organizing Committee Meeting, Yerby Center; AAPS-SRDG Student Liaisons Meeting, Yerby Center

Friday, May 29, 1998 (Yerby Center)
7:00 a.m. - 7:45 a.m.
Registration, Continental Breakfast

7:45 a.m. - 8:00 a.m.
Welcoming Remarks (School of Pharmacy, Dean Kenneth B. Roberts and Dr. Alan B. Jones; AAPS-SRDG, Dr. Hamid Ghandehari)

8:00 a.m. - 8:45 a.m.
Keynote Address (Dr. Jindrich Kopecek, The University of Utah)

8:45 a.m. - 10:00 a.m.
Podium Session I

10:00 a.m. - 10:15 a.m. Coffee Break

10:15 a.m. - 11:00 a.m.
Invited Speaker (Dr. Marvin C. Meyer, The University of Tennessee)

11:00 a.m. - 12:15 p.m.
Podium Session II

12:15 p.m. - 1:15 p.m.
Lunch (will be provided)

1:15 p.m. - 2:00 p.m.
Invited Speaker (Dr. Alice M. Clark, The University of Mississippi)

2:00 p.m. - 3:30 p.m.
Poster Session

3:00 p.m. - 3:30 p.m.
Refreshments

3:30 p.m. - 4:45 p.m.
Podium Session III

4:45 p.m. - 5:00 p.m.
The Awards Ceremony, Closing Remarks (Dr. Indra K. Reddy, Northeast Louisiana University)

AAPS-SRDG Podium Sessions

Keynote Address
8:00 a.m. - 8:45 a.m.

POLYMERIC ANTICANCER DRUGS: FROM DESIGN TO CLINICAL TRIALS
Jindrich Kopecek
Professor, Departments of Pharmaceutics and Pharmaceutical Chemistry/Center for Controlled Chemical Delivery, and of Bioengineering, The University of Utah, Salt Lake City, Utah

Podium Session I

Moderator: Mansoor A. Khan
Associate Professor, Division of Basic Pharmaceutical Sciences Northeast Louisiana University, Monroe, Louisiana

8:45 a.m.
STRATEGIES TO STABILIZE PROTEINS AGAINST DENATURING EFFECTS OF LIQUID/LIQUID INTERFACE
H. Sah
The University of Tennessee College of Pharmacy, Memphis, Tennessee

9:10 a.m.
THE PHARMACOKINETICS OF CHLORPHENIRAMINE, PHENYTOIN, NIFEDIPINE AND GLIPIZIDE IN AN INDIVIDUAL HOMOZYGOUS FOR THE LEU359 ALLELE OF CYP2C9.
R. S. Kidd1, A. B. Straughn1, M. C. Meyer1, J. Goldstein2, J. T. Dalton1
1Department of Pharmaceutical Sciences, The University of Tennessee, Memphis, Tennessee; 2National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina

9:35 a.m.
DOES PAROXYSMAL DYSTONIA HAVE A SENSORY/ANXIETY DISORDER ETIOLOGY?
W. B. Iturrian, S. J. Ramshur, A. E. Khalifa
College of Pharmacy, University of Georgia, Athens, Georgia

Coffee Break (10:00 a.m. - 10: 15 a.m.)

Invited Speaker
10:15 a.m. - 11:00 a.m.
THE USE OF ARTIFICIAL NEURAL NETWORKS IN THE DESIGN OF CONTROLLED- RELEASE DOSAGE FORMS
Marvin C. Meyer
Professor and Chair, Department of Pharmaceutical Sciences, and Associate Dean for Research Training, College of Pharmacy, The University of Tennessee, Memphis, Tennessee

AAPS-SRDG Podium Sessions

Podium Session II

Moderator: James T. Dalton
Associate Professor, Department of Pharmaceutical Sciences
The University of Tennessee, Memphis, Tennessee

11:00 a.m.
TISSUE DISTRIBUTION OF R-[125I] IODO-BICALUTAMIDE, A NOVEL PROSTATE IMAGING AGENT, IN RATS
A. Mukherjee, L. Kirkovsky, D. D. Miller, J. T. Dalton
Department of Pharmaceutical Sciences, The University of Tennessee, Memphis, Tennessee

11:25 a.m.
INTERSPECIES COMPARISON OF COCAETHYLENE FORMATION

N. Song, R. B. Parker, S. C. Laizure
Department of Clinical Pharmacy, The University of Tennessee, Memphis, Tennessee

11:50 a.m.
ENANTIOSELECTIVE TRANSDERMAL PERMEATION AND PREDICTION OF FLUX RATIOS OF KETOPROFEN USING MTMT HYPOTHESIS
T. R. Kommuru, M. A. Khan, I. K. Reddy
Division of Basic Pharmaceutical Sciences, School of Pharmacy, Northeast Louisiana University, Monroe, Louisiana

Lunch (12:15 p.m. - 1:15 p.m.)

Invited Speaker
1:15 p.m. - 2:00 p.m.
THE SEARCH FOR MECHANISTICALLY AND STRUCTURALLY NOVEL BIOACTIVE NATURAL PRODUCTS
Alice M. Clark
Professor of Pharmacognosy and Director of National Center for the Development of Natural Products, The School of Pharmacy, The University of Mississippi, University, Mississippi.
Poster Session and Refreshments (2:00 p.m. - 3:30 p.m.)

Podium Session III

Moderator: Diane S. Swaffer
Associate Professor, Division of Basic Pharmaceutical Sciences Northeast Louisiana University, Monroe, Louisiana

3:30 p.m.
THE EFFECT OF HORMONAL FLUCTUATION DURING THE MENSTRUAL CYCLE ON THE PHARMACOKINETICS OF TOBRAMYCIN
R. S. Kidd, A. B. Straughn
Department of Pharmaceutical Sciences, The University of Tennessee, Memphis, Tennessee

3:55 p.m.
CARDIAC HYPERTROPHIC STIMULATION BY ANABOLIC-ANDROGENIC STEROIDS: PUTATIVE ROLE FOR ERK, JNK, AND PKC SIGNALING PATHWAYS
R. B. Melchert, H. Wang, L. G. Jones
Department of Biopharmaceutical Sciences, The University of Arkansas for Medical Sciences, Little Rock, Arkansas

4:20 p.m.
SYNTHESIS AND BIOASSAY OF SEMI-SYNTHETIC ANALOGS OF OLEANOLIC ACID AS POTENTIAL COMPLEMENT INHIBITORS
H. Assefa1, A. Nimrod2, L. Walker2,3, R. Sindelar1,2
1Department of Medicinal Chemistry, 2National Center for the Development of Natural Products, 3Department of Pharmacology, The School of Pharmacy, The University of Mississippi, University, Mississippi

AAPS-SRDG Poster Session
Posters will be mounted prior to 7:45 a.m., and will stay on the boards until 5:00 p.m. Presenters will be present from 2:00 p.m. to 3:30 p.m.

Moderators: Bonnie A. Avery and William M. Kolling

(1) A SAFE AND EFFICIENT PREPARATION OF 2-ADAMANTYLAMINES USING A NOVEL REDUCTIVE AMINATION METHODOLOGY
P. Ross, K. A. Neidigh, M. A. Avery, S. Bhattacharyya, J. S. Williamson
Departments of Medicinal Chemistry and Chemistry, and National Center for the Development of Natural Products, The University of Mississippi, University, Mississippi

(2) PRODUCTION OF PYRIDYLAMINE DERIVATIVES OF NICOTINE VIA A NEW REDUCTIVE AMINATION TECHNIQUE
M. Gallotte, K. A. Neidigh, M. A. Avery, S. Bhattacharyya, J. S. Williamson
Departments of Medicinal Chemistry and Chemistry, and National Center for the Development of Natural Products, The University of Mississippi, University, Mississippi

(3) DISCOVERY OF NON STEROIDAL ANDROGENS
D.Yin, A. Mukherjee, L. Kirkovsky, Y. Kimura, D. Miller, J. T. Dalton
Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee, Memphis, Tennessee

(4) EVIDENCE FOR THE INHIBITION OF NUCLEAR ENZYME TOPOISOMERASE II BY TAXOL
V. Dhawan, D. S. Swaffar
School of Pharmacy, Northeast Louisiana University, Monroe, Louisiana

(5) EPHEDRINE-TYPE ALKALOID CONTENT OF NUTRITIONAL SUPPLEMENTS CONTAINING EPHEDRA SINICA (MA-HUANG)
B. J. Gurley, P. Wang, S. F. Gardner
Departments of Pharmaceutics and Pharmacy Practice, The University of Arkansas for Medical Sciences, Little Rock, Arkansas

(6) DETERMINATION OF 5-AMINOLEVULINIC ACID (ALA) IN HUMAN PLASMA SAMPLES BY HPLC
Y. Chen, M. C. Meyer, A. B. Straughn, D. Young
Department of Pharmaceutical Sciences, The University of Tennessee, Memphis, Tennessee

(7) DEVELOPMENT OF AN HPLC METHOD FOR THE ANALYSIS OF ARTEMISININS USING AN EVAPORATIVE LIGHT SCATTERING DETECTOR
N. H. Vyas, K. K. Venkatesh, B. A. Avery, M. A. Avery, A. B. Jones
Departments of Pharmaceutics and Medicinal Chemistry, National Center for the Development of Natural Products, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi

(8) STATISTICAL EXPERIMENTAL DESIGN IN PREFORMULATION AND FORMULATION DEVELOPMENT
D. M. Oakley
Pharmaceutical Research and Development, Schering-Plough HealthCare Products, Inc., Memphis, Tennessee

(9) THERMAL CHARACTERIZATION OF PLURONIC F-127 GELS
V. Sharma, A. B. Jones, W. M. Kolling, C. M. Wyandt
Department of Pharmaceutics and National Center for the Development of Natural Products, The University of Mississippi, University, Mississippi

(10) FORMULATION DEVELOPMENT AND STABILITY EVALUATION OF A MULTICOMPONENT NUTRITIONAL SUPPLEMENT.
S. R. Vaithiyalingam1, V. Agarwal1, S. Nazzal1, M. Ashraf2, M. A. Khan1
1Division of Basic Pharmaceutical Sciences, Northeast Louisiana University, Monroe, Louisiana, 2Wyeth Ayerst Research, Pearl River, New York

(11) SOLID-STATE NON-ISOTHERMAL GRAVIMETRIC ANALYSIS OF THE DESOLVATION KINETICS OF THREE PENICILLIN-DERIVATIVE MONOHYDRATES
S. P. Stodghill1, C. M. Wyandt1,2,3
1Department of Pharmaceutics, 2National Center for the Development of Natural Products, 3Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, Mississippi

(12) ATENOLOL GASTROINTESTINAL THERAPEUTIC SYSTEM : SOLID STATE STABILITY ASSESSMENT
S. R. Vaithiyalingam, S. V. Sastry, V. Agarwal, S. Nazzal, I. K. Reddy, M. A. Khan
Division of Basic Pharmaceutical Sciences, Northeast Louisiana University, Monroe, Louisiana

(13) EFFECT OF POLYMER RATIO ON THE RELEASE OF NITROFURANTOIN FROM MUCOADHESIVE TABLETS L.
A. Bostanian, I. Womack, N. Elebeke, M. Chokele, T. K. Mandal
College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana

(14) PROCESSING EFFECTS AND COMPRESSION CHARACTERISTICS OF TABLET COMPACTS MADE WITH DIFFERENT CALCIUM CARBONATE GRADES
G. A. Cox, E. L. Brunson
Schering-Plough HealthCare Products, Inc., Memphis, Tennessee

(15) GENETIC ENGINEERING OF STIMULI-SENSITIVE SILK-ELASTIN LIKE BLOCK COPOLYMERS
H. Ghandehari1, M. Crissman2, J. Crissman2, F. Ferrari2, J. Cappello2, A. Nagarsekar1
1Department of Pharmaceutics and National Center for the Development of Natural Products, The University of Mississippi, The University, Mississippi, 2Protein Polymer Technologies, Inc., San Diego, California

(16) IN VITRO STUDIES OF ARTEETHER LIPOSOMES
K. S. Gokhale1, H. N. Elsohly2, A. H. Hikal1,2
1Department of Pharmaceutics, 2National Center for the Development of Natural Products, The University of Mississippi, University, Mississippi AAPS-SRDG Poster Session

(17) ANTICANCER DRUG COMBINATION EVALUATION ON TISSUE CULTURE MODELS
J. G. Eley1, E. Felts1, S. M. Schmid2
1Samford University; 2Experimental Therapeutics Department, Southern Research Institute, Birmingham, Alabama

(18) TRANSPORT MECHANISM OF PELDESINE (BCX-34) IN CACO-2 MONOLAYERS
H. J. Irving1, A. H. Hikal1,2, T. X. Viegas3
1Department of Pharmaceutics, 2National Center for the Development of Natural Products, School of Pharmacy, The University of Mississippi, University, Mississippi, 3BioCryst Pharmaceuticals, Inc., Birmingham, Alabama

(19) COMPUTER MODELING OF THE SOLUTION CONFORMATIONS OF RGD AND THREE METHYL ANALOGS
R. Sharan, W. Kolling, H. Ghandehari
Department of Pharmaceutics, School of Pharmacy and the National Center for the Development of Natural Products, The University of Mississippi, University, Mississippi

(20) RABBIT CORNEAL CELL LINE (SIRC): A NEW IN VITRO MODEL FOR STUDYING THE EPITHELIAL TRANSPORT OF DRUGS
V. R. Goskonda, M. A. Khan, I. K. Reddy
Division of Basic Pharmaceutical Sciences, Northeast Louisiana University, Monroe, Louisiana

(21) NEW APPROACHES TO ANTIFUNGAL TESTING
S. G. Lalchandani1, S. R. Telang1, A. C. Nimrod2, A. H. Hikal1,2
1Department of Pharmaceutics, 2National Center for the Development of Natural Products, The University of Mississippi, University, Mississippi

(22) EFFECT OF GRAPEFRUIT JUICE ON THE SYSTEMIC AVAILABILITY OF ITRACONAZOLE (ITZ) CAPSULES
S. R. Penzak, P. O. Gubbins, B. J. Gurley, P. L. Wang, M. Saccente
The University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, Arkansas

(23) METABOLISM STUDIES OF MAESANIN
E. A. Abourashed1, F. S. El- Feraly3, I. Khan2, R. Bauer4, C. D. Hufford1,2
1Department of Pharmacognosy, 2National Center for the Development of Natural Products, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi; 3Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 4Institut fur Pharmazeutische Biologie, Universitat Dusseldorf, Germany

(24) ANTICONVULSANT ACTIVITY OF SYSTEM-L INHIBITION
M. S. Luer, M. L. Shannon, B. Gurley
Departments of Pharmacy Practice and Pharmaceutics, The University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, Arkansas

(25) STEREOSELECTIVE INTERACTIONS OF IBUPROFEN ISOMERS ON PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE (PGHS) AND PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR_ (PPAR__
B. Wongsud1, S. M. Rangwala1, M. S. Jaradat1, G. Shams2, M. Sutton2, K. J. Romstedt, D. R. Feller1,2
1Department of Pharmacology, National Center for the Development of Natural Products, The University of Mississippi, University, Mississippi, 2Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio