AAPS PharmSci - Pharmacogenetics - Pharmacogenomics 2001-2002

Editors: Maureen Cronin and B. Michael Silber

Table of Contents

Pharmacogenetics-Pharmacogenomics Virtual Journal

Reviews

Genetic Variations in Human G Protein-Coupled Receptors: Implications for Drug Therapy
Wolfgang Sadee, Elen Hoeg, Julie Lucas and Danxin Wang

Role of MRP4 and MRP5 in Biology and Chemotherapy
Janardhan Sampath, Masashi Adachi, Sigrid Hatse, Lieve Naesens, Jan Balzarini, Robin Flatley, Larry Matherly and John Schuetz

Commentaries

Pharmacogenomics: The Implementation Phase
Wolfgang Sadee

Genotyping and Drug Response: Use of Single Nucleotide Polymorphisms (SNPs) versus Haplotypes to Predict Albuterol Efficacy
Suzanne Schubbert

UGT1A1 Polymorphism Predicts Irinotecan Toxicity: Evolving Proof
Sridhar Mani

The MDR1 C3435T polymorphism: Effects on P-glycoprotein expression/function and clinical significance
Mark J. Dresser

Original Research Articles

Receptor Binding Studies of Soft Anticholinergic Agents
Fenglei Huang, Peter Buchwald, Clinton E. Browne, Hassan H. Farag, Whei-Mei Wu, Fubao Ji, Guenther Hochhaus and Nicholas Bodor

Single Nucleotide Polymorphisms of the Human M1 Muscarinic Acetylcholine Receptor Gene
Julie L. Lucas, Joseph A. DeYoung and Wolfgang Sadee

cDNA Microarray Analysis of Vascular Gene Expression After Nitric Oxide Donor Infusions in Rats: Implications for Nitrate Tolerance Mechanisms
Ellen Q. Wang, Woo-In Lee, Daniel Brazeau and Ho-Leung Fung

Cloning and Characterization of the Rat Multidrug Resistance-Associated Protein 1
Ziping Yang, Cheryl Li, Danny Shen and Rodney Ho

Bioinformatic Analysis of the Human µ Opioid Receptor (OPRM1) Splice and Polymorphic Variants
Lili Xin and Zaijie Jim Wang

Detection of MDR1 Single Nucleotide Polymorphisms C3435T and G2677T Using Real-Time Polymerase Chain Reaction: MDR1 Single Nucleotide Polymorphism Genotyping Assay
Pengfei Song, Shen Li, Bernd Meibohm, A. Osama Gaber, Marsha R. Honaker, Malak Kotb and Charles R. Yates