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Granulation: Endpoint Theory, Instrumentation, and Scale-Up

THE CD-ROM VERSION

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By Michael Levin, Ph.D.
Metropolitan Computing Corporation
East Hanover, NJ

Technical Platform and Requirements:

This 65-minute course is contained within a standard CD-ROM. Requirements include a 486 or faster PC running Windows 95 or 98, a CD-ROM player,  sound card, and speakers. Included on the disk is a copy of PowerPoint 97 Viewer, which is required to view the course content, and which must be installed in the default directory in order to properly utilize the menu-driven program.

Who Should Participate:

This course is designed for formulation scientists, scale-up engineers, and general granulation personnel who would like to expand their understanding of the reasons behind various granulation scale-up problems and to investigate the practical solutions to such problems.

SPECIAL FEATURES

Two contact hours (0.2 CEU) will be awarded for successful completion of multiple choice test (ACPE number: 073-999-99.073-H04).

Extensive references and notes in convenient hard-copy format.

Purchase Price:   Members - $150
Non-members - $225

CLICK HERE FOR ORDER FORM

Course Outline:

This course will follow the outline of Dr. Levin's Arden House presentation...

*  Instrumentation for a mixer-granulator
*  Theory and practice aspects of end-point determination
*  Dimensional analysis as a basis for a reliable process scale-up

Course Goals and Objectives:

In recent years, there has been a resurgence of interest in technology, theory, and applications of a granulation process monitoring. Measurements of torque, power, speed, and temperature are of vital importance for understanding the change in the cohesive force or the tensile strength of the agglomerates in the moistened power bed. Mixer specific transducer designs for effective measurements must be combined with a detailed real time analysis of the incoming information for a reliable product and process optimization.

This course will present the classic theory of granulation end point determination and will provide a review of recent studies performed on a variety of vessel geometrics and a range of batch sizes. The goal of this course is to indicate a scientifically reliable way to minimize batch-to-batch variability and to ensure consistency of product properties during the scale-up process.

Presenter Bio:

Dr. Michael Levin is the President of Metropolitan Computing Corporation (MCC) specializing in analytical instrumentation and data acquisition systems for tablet presses, mixers, roller compactors and other equipment. Prior to forming MCC in 1985, he has been a consultant to such pharmaceutical companies as Merck, Sandoz, and Warner-Lambert. He received his Ph.D. in BioMathematics (1980) from University of Washington in Seattle. He is a member of the AAPS, ISPE, and BMES.

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