
| By Michael
Levin, Ph.D. Metropolitan Computing Corporation East Hanover, NJ
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Technical Platform
and Requirements: This 65-minute
course is contained within a standard CD-ROM. Requirements include a 486 or faster PC
running Windows 95 or 98, a CD-ROM player, sound card, and speakers. Included on the
disk is a copy of PowerPoint 97 Viewer, which is required to view the course content, and
which must be installed in the default directory in order to properly utilize the
menu-driven program.
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Who Should
Participate: This course is designed
for formulation scientists, scale-up engineers, and general granulation personnel who
would like to expand their understanding of the reasons behind various granulation
scale-up problems and to investigate the practical solutions to such problems.
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SPECIAL FEATURES
| Two contact hours (0.2 CEU) will be awarded for successful completion of
multiple choice test (ACPE number: 073-999-99.073-H04). Extensive references and notes in convenient hard-copy format.
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| Course Outline: This course will follow the outline of Dr. Levin's Arden House
presentation...
* Instrumentation for a mixer-granulator * Theory and practice aspects of end-point determination * Dimensional analysis as a basis for a reliable process scale-up
Course Goals and
Objectives: In recent years, there has
been a resurgence of interest in technology, theory, and applications of a granulation
process monitoring. Measurements of torque, power, speed, and temperature are of vital
importance for understanding the change in the cohesive force or the tensile strength of
the agglomerates in the moistened power bed. Mixer specific transducer designs for
effective measurements must be combined with a detailed real time analysis of the incoming
information for a reliable product and process optimization.
This course will present the classic theory of granulation
end point determination and will provide a review of recent studies performed on a variety
of vessel geometrics and a range of batch sizes. The goal of this course is to indicate a
scientifically reliable way to minimize batch-to-batch variability and to ensure
consistency of product properties during the scale-up process.
Presenter Bio: Dr. Michael Levin is the President of
Metropolitan Computing Corporation (MCC) specializing in analytical instrumentation and
data acquisition systems for tablet presses, mixers, roller compactors and other
equipment. Prior to forming MCC in 1985, he has been a consultant to such pharmaceutical
companies as Merck, Sandoz, and Warner-Lambert. He received his Ph.D. in BioMathematics
(1980) from University of Washington in Seattle. He is a member of the AAPS, ISPE, and
BMES.
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